解硫胺素类芽孢杆菌(Paenibacillus thiaminolyticus)

简介

     解硫胺素类芽孢杆菌(Paenibacillus thiaminolyticus)属于类芽孢杆菌科(Paenibacillaceae)。革兰染色有阴有阳。

临床相关性

       分离自人粪便和蜜蜂幼虫，偶见引起菌血症、术后伤口感染、眼玻璃体感染、脑炎（ encephalitis）、婴儿脑膜炎等。

药敏试验

      肉汤稀释法（裂解马血阳离子调节肉汤）检测MIC，受试抗生素及其折点参考M45ED3 Table4；培养中遇到芽孢杆菌通常认为是污染菌。对分离自无菌部位标本（如深部组织，脑脊液，多套阳性血培养）、植入假体装置，来自免疫缺陷患者或有静脉毒品注射史患者的菌株需要药敏试验。

参考文献

1.EricsonJE,etal.NeonatalPaenibacilliosis:Paenibacillus Infection as a Novel Cause of Sepsis in Term Neonates With High Risk of Sequelae in Uganda. Clin Infect Dis.2025 Sep 11;77(5):768-775.

2.Di Micco R,et al.Postoperative Paenibacillusthiaminolyticus Wound Infection, Switzerland.Emerg Infect Dis.2021 Jul;27(7):1984-1986.

3.Smallcomb LS,et al.A rare case of neonatalmeningoencephalitis from Paenibacillus thiaminolyticus. Access Microbiol.2022Dec5;4(12):acmi000430.

4.Hunt B,et al.Paenibacillus Sepsis and Meningitis in a Premature Infant: A Case Report.AmJForensic Med Pathol.2021 Mar 1;42(1):96-98.